Medical Instruments Encyclopedia
Home > Medical Instruments Encyclopedia
HER-2/neu Gene Detection Kit (Fluorescence In Situ Hybridization)
The HER-2/neu Gene Detection Kit is composed of hybridization solution and DAPI counterstain. These components are essential for the accurate detection of HER-2/neu gene amplification in breast cancer tissue samples. The kit is designed for use with formalin-fixed, paraffin-embedded (FFPE) tissue sections, ensuring compatibility with standard laboratory protocols.
Product English Name:
HER-2/neu Gene Detection Kit (Fluorescence In Situ Hybridization)
Alias:
FISH HER-2/neu Kit,HER-2 FISH Detection Kit
Intended Use:
This kit is used for the qualitative detection of HER-2/neu gene amplification (17q12) in paraffin-embedded breast cancer tissue sections from patients diagnosed with breast cancer. It aids in determining the HER-2 status, which is crucial for guiding targeted therapy decisions in breast cancer treatment.
Product Introduction

The HER-2/neu Gene Detection Kit is a specialized diagnostic tool designed for the precise detection of HER-2/neu gene amplification in breast cancer tissue samples. Utilizing fluorescence in situ hybridization (FISH) technology, this kit provides accurate and reliable results, essential for determining the HER-2 status of breast cancer patients. The kit is compatible with standard laboratory protocols and is widely used in clinical settings to guide targeted therapy decisions.

1. The HER-2/neu Gene Detection Kit is characterized by its high sensitivity and specificity, ensuring accurate detection of HER-2/neu gene amplification. The kit utilizes advanced FISH technology, which allows for the visualization of gene amplification at the cellular level, providing detailed insights into the genetic alterations associated with breast cancer.
2. The kit is composed of hybridization solution and DAPI counterstain. The hybridization solution facilitates the binding of fluorescent probes to the target DNA sequences, while the DAPI counterstain is used to visualize the nuclei, aiding in the accurate interpretation of the FISH results. These components are carefully formulated to ensure optimal performance and reliability.
3. The primary use of the HER-2/neu Gene Detection Kit is to determine the HER-2 status of breast cancer patients. HER-2 status is a critical factor in guiding targeted therapy decisions, as HER-2-positive breast cancers may benefit from specific targeted therapies. The kit is widely used in clinical laboratories to provide accurate and reliable results, aiding in the personalized treatment of breast cancer patients.

The HER-2/neu Gene Detection Kit, also known as the FISH HER-2/neu Kit, is a vital tool in the diagnosis and treatment of breast cancer. Its high sensitivity and specificity make it an indispensable resource for clinicians, enabling them to make informed decisions about targeted therapies. The kit's components, including the hybridization solution and DAPI counterstain, are meticulously designed to ensure accurate and reliable results, ultimately improving patient outcomes.

Main Features

The HER-2/neu Gene Detection Kit offers high sensitivity and specificity in detecting HER-2/neu gene amplification. It utilizes FISH technology for precise visualization of gene alterations, making it a reliable tool for clinical diagnostics.

1. The kit provides high sensitivity in detecting HER-2/neu gene amplification, ensuring accurate results even in low-abundance samples. This feature is crucial for identifying patients who may benefit from targeted therapies.
2. The specificity of the kit is optimized to minimize false positives, ensuring that only true HER-2/neu gene amplifications are detected. This reduces the risk of misdiagnosis and ensures appropriate treatment decisions.
3. The FISH technology used in the kit allows for the visualization of gene amplification at the cellular level, providing detailed insights into the genetic alterations associated with breast cancer. This level of detail is essential for accurate diagnosis and treatment planning.
4. The kit is designed for compatibility with standard laboratory protocols, making it easy to integrate into existing workflows. This ensures that laboratories can quickly adopt the kit without significant changes to their procedures.
5. The HER-2/neu Gene Detection Kit is widely used in clinical settings, providing reliable results that guide targeted therapy decisions. Its accuracy and reliability make it a trusted tool for clinicians in the treatment of breast cancer.

The HER-2/neu Gene Detection Kit stands out for its high sensitivity and specificity, making it a reliable tool for detecting HER-2/neu gene amplification. Its use of FISH technology provides detailed insights into genetic alterations, aiding in accurate diagnosis and treatment planning. The kit's compatibility with standard laboratory protocols ensures easy integration into clinical workflows, making it a valuable resource for clinicians.

Clinical Applications

The HER-2/neu Gene Detection Kit is widely used in clinical settings to determine the HER-2 status of breast cancer patients. This information is crucial for guiding targeted therapy decisions and improving patient outcomes.

1. The kit is used in clinical laboratories to detect HER-2/neu gene amplification in breast cancer tissue samples. This information is essential for determining the HER-2 status of patients, which guides the selection of targeted therapies.
2. The accurate detection of HER-2/neu gene amplification provided by the kit helps clinicians identify patients who may benefit from HER-2-targeted therapies, such as trastuzumab. This improves the chances of successful treatment outcomes.
3. The kit is also used in research settings to study the genetic alterations associated with breast cancer. Its high sensitivity and specificity make it a valuable tool for understanding the molecular basis of the disease.
4. In clinical trials, the HER-2/neu Gene Detection Kit is used to assess the efficacy of new targeted therapies. Its reliable results provide valuable data for evaluating the effectiveness of these treatments.
5. The kit is widely used in routine clinical practice to monitor the HER-2 status of breast cancer patients over time. This helps clinicians adjust treatment plans as needed, ensuring optimal patient care.

The HER-2/neu Gene Detection Kit plays a crucial role in clinical practice, providing accurate and reliable results that guide targeted therapy decisions. Its use in both clinical and research settings makes it a versatile tool for understanding and treating breast cancer. The kit's ability to monitor HER-2 status over time ensures that patients receive the most appropriate and effective treatments.

Purchasing Guide

When purchasing the HER-2/neu Gene Detection Kit, it is important to consider product specifications, types, budget, and intended use to ensure the best fit for your laboratory's needs.

1. Product specifications are a key consideration when purchasing the HER-2/neu Gene Detection Kit. Ensure that the kit meets the sensitivity and specificity requirements of your laboratory, and that it is compatible with your existing equipment and protocols.
2. The type of kit you choose should align with your laboratory's needs. Consider whether you require a standard kit or one with additional features, such as enhanced sensitivity or compatibility with specific tissue types.
3. Budget is an important factor in the purchasing decision. While the HER-2/neu Gene Detection Kit is a valuable tool, it is essential to ensure that it fits within your laboratory's budget without compromising on quality or performance.
4. The intended use of the kit should also be considered. If the kit will be used in a high-throughput setting, ensure that it is designed for such use and can handle the volume of samples your laboratory processes.

Purchasing the HER-2/neu Gene Detection Kit requires careful consideration of product specifications, types, budget, and intended use. By taking these factors into account, you can ensure that the kit meets your laboratory's needs and provides reliable results for accurate diagnosis and treatment planning.

 Precautions

Proper handling and storage of the HER-2/neu Gene Detection Kit are essential to ensure accurate results and maintain the integrity of the components.

1. The HER-2/neu Gene Detection Kit should be stored at the recommended temperature to maintain the stability of the hybridization solution and DAPI counterstain. Improper storage can lead to degradation of the components, affecting the accuracy of the results.
2. It is important to follow the manufacturer's instructions for handling the kit components. This includes proper mixing of the hybridization solution and correct application of the DAPI counterstain to ensure accurate visualization of the FISH results.
3. The kit should be used within its expiration date to ensure optimal performance. Using expired components can lead to unreliable results and potential misdiagnosis.
4. Proper disposal of the kit components is essential to prevent contamination and ensure laboratory safety. Follow local regulations for the disposal of hazardous materials.
5. Regular calibration and maintenance of the fluorescence microscope used with the kit are necessary to ensure accurate visualization of the FISH results. Poorly maintained equipment can lead to misinterpretation of the results.

The HER-2/neu Gene Detection Kit requires careful handling and storage to ensure accurate results. Proper storage, handling, and disposal of the kit components are essential to maintain the integrity of the results and ensure laboratory safety. Regular maintenance of the fluorescence microscope is also necessary to ensure accurate visualization of the FISH results.

Easy procurement

We have the latest medical device product database in China, which can quickly meet your procurement needs.

Submit your purchase list, and we will reply to your inquiry within half an hour at the earliest.

Quickly respond to your procurement needs:
Upload your purchase list
Support EXCEL/PDF/Word/compressed files